Liver-X ReceptorEndocrine disruption: Estimation of the binding affinity of small molecules towards the Liver-X receptor.
Diseases of the heart and circulatory system (cardio¬vascular diseases or CVDs) are the direct cause of more than four million deaths per year in Europe, corresponding to 43% of all deaths of all ages in men and 55% in women. Elevated plasma cholesterol levels are a major risk factor in CVDs, being correlated with coronary heart diseases and stroke, and promote atherosclerosis. Liver X Receptors (LXRs) — members of a superfamily of nuclear hormone receptors and represented by two subtypes, LXRα and LXRβ — have been shown to be involved in cholesterol homeo¬stasis. LXRs are ligand-dependent transcription factors that form permissive heterodimers with the retinoid X receptor (RXR) to regulate the expression, directly or indirectly, of a number of genes involved in cholesterol and fatty acid metabolism.
LiverX receptor with bound ochratoxin A.
Comparison of experimental and predicted Ki values for the Liver X receptor
(training set = black, test set = red).